Recently, Yankner and his colleagues discovered that a protein called Rest is very active in the aging brain, but is relatively absent in the brain of cognitive impairment or Alzheimer's disease. This discovery may avoid nerve regression. Sexual diseases.
The researchers measured the content of this Rest protein in the aging brain and found that when the person died, in their prefrontal cortex, the frontal part of the brain involved in planning, personality, and other cognitive functions was more than 3 times higher. This protein. This finding suggests that clinical signs of plaque and other Alzheimer's disease may not be enough to cause dementia, and yankner said that it seems that the loss of Rest protein may also be at work.
The researchers found that the Rest protein is not the brain that left Alzheimer's patients. In contrast, their brain cells also produce this protein, but cells called autophagosomes engulf and degrade.
Therefore, by intervening and preventing the degradation of these proteins, it becomes possible for scientists to diagnose or prevent Alzheimer's disease and dementia. Researchers are investigating whether the levels of other proteins in the brain can also be used to diagnose brain health. By looking at how much of this protein is produced in other cells of the body, it may be possible to infer changes in the brain, the researchers said.
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